{"id":10858,"date":"2024-05-06T09:22:44","date_gmt":"2024-05-06T14:22:44","guid":{"rendered":"https:\/\/www.wisconsin.edu\/all-in-wisconsin-new\/?post_type=campus_story&p=10858"},"modified":"2024-05-06T09:22:44","modified_gmt":"2024-05-06T14:22:44","slug":"uw-madison-researchers-develop-better-way-to-make-painkiller-from-trees","status":"publish","type":"campus_story","link":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/story\/uw-madison-researchers-develop-better-way-to-make-painkiller-from-trees\/","title":{"rendered":"UW\u2013Madison researchers develop better way to make painkiller from trees"},"content":{"rendered":"
\"Photo<\/a>
Scientists Steve Karlen and Vitaliy Tymokhin look over a reactor they used for their research on converting biomass into paracetamol.<\/figcaption><\/figure>\n

Scientists at the University of Wisconsin\u2013Madison have developed a cost-effective and environmentally sustainable way to make a popular pain reliever and other valuable products from plants instead of petroleum.<\/p>\n

Building on a previously patented method for producing paracetamol \u2013 the active ingredient in Tylenol \u2013 the discovery promises a greener path to one of the world\u2019s most widely used medicines and other chemicals. More importantly, it could provide new revenue streams to make cellulosic biofuels \u2014 derived from non-food plant fibers \u2014 cost competitive with fossil fuels, the primary driver of climate change.<\/p>\n

\u201cWe did the R&D to scale it and make it realizable,\u201d says Steven Karlen, a staff scientist at the Great Lakes Bioenergy Research Center who led the research\u00a0published recently in the journal ChemSusChem<\/a>.<\/p>\n

Paracetamol, also known as acetaminophen, is one of the most widely used pharmaceuticals, with a global market value of about $130 million a year. Since it was introduced in the early 1900s, the drug has traditionally been made from derivatives of coal tar or petroleum.<\/p>\n

In 2019, Karlen and UW\u2013Madison biochemistry professor John Ralph\u00a0showed how it could be made instead<\/a>\u00a0from a compound in poplar trees using a well-known chemical reaction.<\/p>\n

Now Karlen\u2019s team has improved the process for making paracetamol as well as other drugs, pigments, textiles, and biodegradable plastics with a cumulative market value of more than $1.5 billion, a portfolio of products that Karlen says could support dozens of small biorefineries feeding into larger hubs without saturating the market.<\/p>\n

The process is available for commercial licensing through the\u00a0Wisconsin Alumni Research Foundation<\/a>, the nonprofit organization that commercializes university discoveries to support ongoing research.<\/p>\n

The paracetamol molecule is made of a six-carbon benzene ring with two chemical groups attached. Poplar trees produce a similar compound called\u00a0p<\/em>-hydroxybenzoate (p<\/em>HB) in lignin, the part of the cell wall that binds plant sugars together and provides structure.<\/p>\n

Lignin is chock full of valuable aromatic compounds that could replace many petrochemicals and provide biorefineries with additional revenue streams to make plant-based fuels cost competitive. The challenge is breaking down the complex and irregular chain of molecules into useful components.<\/p>\n

It turns out\u00a0p<\/em>HB is relatively easy to break off with chemical treatment, but while the initial discovery showed it was chemically possible to turn it into paracetamol, Karlen says that process didn\u2019t convert enough of the raw material into the final product.<\/p>\n

Research scientist Vitaliy Tymokhin discovered that treating poplar biomass with a different \u2013 and typically cheaper \u2013 method converted nearly all the\u00a0p<\/em>HB into another chemical that can then be converted into paracetamol or a less valuable molecule with other applications.<\/p>\n

\u201cYou can make dyes like black ink, polymers which can be used in textiles or material application, convert it to adhesives or into stuff like that,\u201d Karlen says. \u201cIt\u2019s got a huge market and big value.\u201d<\/p>\n

By recycling the unreacted product back through in a continuous reactor, the scientists successfully converted 90% of the raw material into paracetamol, which they extracted using a method that\u2019s cheaper than traditional purification techniques. Karlen says it should be possible to dial the yield up to 99%.<\/p>\n

The process is primarily water based, relies on green solvents, and is continuous rather than a batch reaction, which makes it ideal for industrial applications.<\/p>\n

\u201cAs I\u2019m chopping the tree up, it can feed right into a reactor that pulls out the benzamide,\u201d Karlen says. \u201cSo you\u2019re never stopping. As fast as your trucks can come in and fill that hopper, you can keep processing.\u201d<\/p>\n

This work was funded by the Office of Science of the U.S. Department of Energy Great Lakes Bioenergy Research Center (DOE BER Office of Science DE-SC0018409).<\/em><\/p>\n

\n

Written by Chris Hubbuch<\/p>\n

Link to original story: https:\/\/news.wisc.edu\/uw-madison-researchers-develop-better-way-to-make-painkiller-from-trees\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Scientists at the University of Wisconsin\u2013Madison have developed a cost-effective and environmentally sustainable way to make a popular pain reliever and other valuable products from plants instead of petroleum. Building on a previously patented method for producing paracetamol \u2013 the active ingredient in Tylenol \u2013 the discovery promises a greener path to one of the […]<\/p>\n","protected":false},"author":15,"featured_media":10860,"comment_status":"closed","ping_status":"closed","template":"","institution":[103],"story_category":[],"class_list":["post-10858","campus_story","type-campus_story","status-publish","has-post-thumbnail","hentry","institution-uw-madison"],"_links":{"self":[{"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/campus_story\/10858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/campus_story"}],"about":[{"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/types\/campus_story"}],"author":[{"embeddable":true,"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/comments?post=10858"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/media\/10860"}],"wp:attachment":[{"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/media?parent=10858"}],"wp:term":[{"taxonomy":"institution","embeddable":true,"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/institution?post=10858"},{"taxonomy":"story_category","embeddable":true,"href":"https:\/\/www.wisconsin.edu\/all-in-wisconsin\/wp-json\/wp\/v2\/story_category?post=10858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}